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Abstract
Using various pain and inflammation models to examine the analgesic and anti-inflammatory effects of various dried Pisonia alba leaf fractions. Rats and mice were used to assess the analgesic efficacy of P.alba using the tail flick test and acetic acid-induced writhing in mice. The anti-inflammatory efficacy of cotton was evaluated using cotton pellet-granuloma development in rats. P.alba was tested at doses of 20 and 40 mg/kg, p.o. in five different fractions (FRI, FRII, FRIII, FRIV, and FRV). The fractions FRI (40 mg/kg, p.o.) and FRIII (40 mg/kg, p.o.) were shown to be more effective (P0.01) than the other fractions at decreasing cotton pellet granuloma formation and acetic acid-induced writhing. FRI (20 mg/kg, p.o.) and FRIII (20 mg/kg, p.o.) were also discovered to be more effective at lengthening latency time in the tail flick method. Two of the five fractions of P. alba leaves examined—FRI and FRIII—show strong analgesic and anti-inflammatory effects against various forms of pain and inflammation.