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A simple and selective LC method is described for the determination of Doxepin dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Triethyl amine: ACN (60:40v/v/v), with detection of 250 nm. Linearity was observed in the range 75-150 µg /ml for Doxepin(r2 =0.999) for drugs estimated by the proposed methods was in good agreement with the label claim quality control department in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies and in clinical pharmacokinetic studies in near future.


Doxepin, Linearity, Quality control, Clinical Pharmacokintic

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