Main Article Content
Abstract
The purpose of the present investigation is to formulate fast dissolving oral films of Loratidine for the treatment of allergic rhinitis and urticaria. Films were prepared by solvent casting method using Natural Polymers Xanthan gum, Guar Gum, Sodium Alginate, Aloe Vera Powder as the film forming polymer and PEG-400 as the plasticizer. Vanillin was used as taste masking agent in the formulations. Sodium Alginate has excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. The concentrations of the polymers and plasticizer were selected as independent variables. Eight formulations were prepared. The thickness, folding Endurance, disintegration time, % drug released and drug content were selected as dependent variables. The optimized formulation, F6 was found superior than remaining 7 batches.