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Ciclopirox ethosomes were prepared using the cold method reported by Touitouetal.(2000) with little modification.  Studies were performed on ethosomes containing 20%, 30%, 40% and 50%w/w ethanol with sonication. Using the same microscopic method and special software “particle size analysis”, size of vesicle was determined for sonicated ethosomes respectively. Vesicular size was found to be in the range of 3.23 – 5.79 µm. After confirm existence of vesicles and their size, drug entrapped by vesicular system was evaluated by ultra-centrifugation.  Sonicated ethosomes containing 50% w/w ethanol showed  higher value i.e., 95.21%.The method described by Touitou et al., (2000) was employed with little modification for the preparation of various ethosomal formulations containing different concentration of ethanol (20 % to 50 %) with sonication. The techniques used were simple and reproducible. The prepared ethosomes were spherical and discrete in shape. The size of vesicles were found to be in the range of 3.26 µm –5.79 µm sonicated ethosomes.


Ciclopirox, ethosomal, ultra-centrifugation, ethanol, particle size analysis

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