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The aim of the present study was to fabricate and evaluate sustained release tablets Nicardipine, using different natural polymers like Guar gum and Xanthum gum which is suitable for delivering the drug for sufficient long time and reduce frequency of dose. The Sustained released tablets containing Nicardipine SR tablets were successfully prepared by wet granulation method. The prepared granules were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 3.11±0.02, average hardness of 7.94±0.05, average weight of 300±0.05, friability of 0.45.The optimized formulation F7 which releases the Nicardipine in sustained manner in 1st hour it releases 9.3% but the remaining drug release was sustained up to 12 hours.


Nicardipine, granulation method, average weight, average hardness, average thickness

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