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The rationale of this investigation was to develop monolithic tablets of loratadine using sublimation technique. Porous tablets of loratadine were prepared by the direct compression technique using sublimating agents like camphor, menthol and cross povidone, CCS as super disintegrants. This dissertation work was done with an aim to design an immediate release oral dosage of Loratadine and evaluation of the tablets for various parameters including in vitro drug release studies. Loratadine tablets were formulated by using microcrystalline cellulose and lactose monohydrate as fillers, camphor and menthol as subliming agents, cross povidone and CCS as super disintegrant and magnesium stearate as lubricant. The formulation F6 is formulated by using subliming agents and super disintegrants where it can ensure burst release of the drug.


Loratadine, CCS, drug release, microcrystalline cellulose, lactose monohydrate

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