Main Article Content
Abstract
Different polymeric Patches containing Ketorolac were prepared and evaluated for physicochemical, in vitro drug release and permeation characteristics. Transdermal patches with ERL 100 and HPMC E15 showed better release than patches with ERS 100 and HPMC E15. The release rate was increased with an increase in HPMC E15 content. Ketorolac transdermal Patches with penetration enhancers d-limonene, oleic acid in 4%, 8% and 12% v/w concentrations were prepared and evaluated for physicochemical and permeation characteristics. The release kinetics of the optimized formulations followed zero order and release mechanism was Non-fickian diffusion rate-controlled mechanism. The transdermal patches of Ketorolac with required flux could be prepared with suitable mechanical properties, further studies are recommended to find their therapeutic utility in humans by pharmacokinetic and pharmacodynamic studies. Immediate release tablets of ketorolac were formulated by direct compression method using menthol as subliming agent, Microcrystalline cellulose as diluent, CCS as super disintegrant, Magnesium stearate as lubricant. Friability values are found to be less than 1% in all the cases and considered to be satisfactory. The total weight of each formulation was maintained constant, and the weight variation of the tablets was within limits.