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Abstract
Repaglinide is an anti-diabetic, oral blood-glucose lowering drug of the meglitinide class used in the management of type-II diabetes mellitus. The present investigation involves formulation and evaluation of mucoadhesive microspheres with repaglinide as model drug for prolongation of drug release time. An attempt was made to develop microspheres of repaglinide by double emulsion solvent evaporation technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mucoadhesive microspheres were formulated by double emulsion solvent evaporation technique using polycarbophil as polymer, the prepared microspheres were evaluated for Flow behaviour, Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, particle shape and size by Scanning Electron Microscopy and Sieving method.