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The purpose of this research was to develop and characterize Bioadhesive buccal tablets of Labetalol using sodium alginate, xanthan gum and Ethylcellulose.  The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release. The swelling index, friability and in vitro drug release. F3 formulation was considered optimum based on good Bioadhesive strength and maximum similarity factor. The drug release from optimum batch followed zero order kinetics with non-Fickian diffusion. Drug and excipients compatibility study showed no interaction between drug and excipients. Stability study of optimized formulation showed that tablets were stable at accelerated environment condition. Thus, buccal adhesive tablet of Labetalol could be an alternative route to bypass hepatic first pass metabolism and to improve bioavailability of Labetalol.


Bioadhesion, buccal drug delivery, Labetalol, polymers, in vitro drug release studies, Zero order kinetics.

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