Main Article Content
Abstract
Buccoadhesive tablets of Venlafaxine HCL were prepared by using Carbopol 934, HPMC K4M and Sodium CMC as mucoadhesive polymers. Nine formulations were developed with varying concentrations of polymers. V1 to V9 formulations were composed of Carbopol 934, HPMC K4M and Sodium CMC in ratios of 1:1, 1:2 and 1:3. The formulated mucoadhesive buccal tablets were assessed for quality attributes like weight variation, hardness, thickness, friability, drug content, moisture absorption, surface pH and in vitro drug release studies. Optimized formulation V4 showed maximum release of the drug (99.72%). The FTIR results showed no evidence of interaction between the drug and polymers. All the evaluation parameters given the positive result and comply with the standards. The results indicated that the mucoadhesive buccal tablets of Venlafaxine HCL may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in bioavailability of Venlafaxine HCL through buccal mucosa.