Main Article Content
Abstract
The aim of this study was to prepare pullulanbased orally disintegrating films (ODFs) containing amlodipine besylate, an antihypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1F9) were prepared by using different plasticizers (glycerol, sorbitol, propylene glycol) and different superdisintegrants (croscarmellose sodium, sodium starch glycolate, crospovidone). FD&C Green and aspartame were used as coloring agent and sweetener, respectively. According to the results of preformulation studies, the optimum ODF (F9) was determined and various characterization studies such as uniformity of mass, film thickness, surface pH of films, and mechanical properties (such as elongation at break, tensile strength, Young's modulus, and folding endurance), moisture content, disintegration time, uniformity of content and dissolution test, X.ray, DSC, SEM and short term stability analysis were performed on this formulation.