Design and invitro evaluation of selegiline patches for transdermal drug delivery system

Abstract

Selegiline, also known as L-deprenyl is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. It is provided in the form of a capsule or tablet taken by mouth for Parkinson's disease and as a patch applied to skin for depression. In present study transdermal drug delivery of Selegiline was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route.