Formulation and evaluation of controlled release matrix tablets of rivastigmine

Abstract

Rivastigmine is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people with alzheimer's disease the main objective of the present study was to develop control release formulation by using natural polymers i.e guar gum, locust bean gum and karaya gum. Direct compression technique was used to prepare tablets which were evaluated for pre compression and post compression parameters. Nine formulations were prepared which f1-f3 were prepared using  guar gum, f4-f6 by locust bean gum and f7-f9 by karaya gum. F6 was selected as the best formulation which controls the drug release up to 99.82% in 12hrs.