Main Article Content
Abstract
The aim of the present study was to develop and evaluate the controlled release tablets by using direct compression method of Miglitol tablet. Controlled release tablets were prepared by employing Sodium alginate, Carbopol 971P and Ethyl cellulose at different concentration. Flow properties – Angle of repose, loose bulk density, tapped density and also % Carr’s compressibility was determined for all the formulations which showed good flow property. The thickness found uniform, hardness and friability values of all the formulation tablets prepared by direct compression method were within the limits and found to be mechanically stable. In vitro dissolution results showed that % of drug release was prolonged in formulation M4 that is up to 12 hours when compared to other formulations. This indicates that the drug released from the formulation M4 was effective up to 12 hours.