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The aim of the present study was to develop and optimize elementary osmotic drug delivery system of betahistinedihydrochloride to give control release of drug by utilizing the osmosis principle with better patient compliance. Suitable analytical method based on uv-visible spectrophotometer developed for betahistinedihydrochloride. By performing preformulation studies by ft-ir, drug-excipient compatability studies, no interaction was confirmed. Prior to compression, drug and granules were evaluated for flow properties such as angle of repose, loose bulk density, tapped bulk density, % compressibility, and hausner’s ratio. The present study shows that the release of bht could be extended over a period of 12 hours through the design of an osmotic drug delivery system by using peo (mw:1,00,000 gm) as swellable polymer , mannitol as osmogen and ethyl cellulose as semi permeable coating membrane. Hence twice a day administration of this ndds can ensure therapeutic concentration throughout the day and can enhance patient compliance.



Betahistinedihydrochloride osmotic drug delivery system Ethyl cellulose

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