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Abstract

Basically, to provide a continuous drug infusion through an intact skin, various transdermal systems have been designed for topical application and it control the delivery of drug and its permeation via the skin tissue. Historically, developments related to TDDS have been incremental, concentrating on overcoming issue related with the skin barrier properties, minimizing skin irritation and improving the outlook related with passive patch systems. TDDS defined as self-contained, discrete dosage form applied to the unharmed skin then it deliver the drug, via skin at controlled manner in the systemic circulation. Transdermal drug delivery via the skin provides a suitable route of administration for a various clinical indications. Captopril is an angiotensin-converting enzyme inhibitor, which reduces peripheral resistance end lowers blood pressure. It is extensively used for the treatment of hypertension and congestive failure. And hence only in our current research we have, fabricated a transdermal delivery system comprising Captopril for the better patient compliance. The transdermal patches were prepared by solution casting technique employing a glass substrate. Membrane type transdermal systems with Captopril prepared using HPMC alone and by employing various proportions of HPMCK15M, PVPK30, and Ethyl Cellulose. It has been observed, that current method for the fabrication of transdermal patches accustom with antihypertensive drug has been found to be significant, conducive and remarkable.

Keywords

Transdermal system Fabrication Evaluation Captopril and drug permeation

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