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Abstract
Co-crystals belong to a sub-class of co-crystals wherein one of the components is a drug molecule (or an active pharmaceutical ingredient, API) and the second is a benign food or drug grade additive (generally regarded as safe, GRAS). The two components are hydrogen-bonded in a fixed stoichiometric ratio in the crystal lattice. In the past decade, pharmaceutical co-crystals have demonstrated significant promise in their ability to modify the physicochemical and pharmacokinetic properties of drug substances, such as the solubility and dissolution rate, bioavailability, particle morphology and size, tabletting and compaction, melting point, physical form, biochemical and hydration stability, and permeability. Quercetin is a challenging molecule to be delivered due to its poor solubility, low hydrophilicity, gastrointestinal instability, extensive first pass metabolism, and minimal absorption in gastrointestinal tract, but has numerous activities including antioxidant, anticancer, hepatoprotective etc., For that reason only, aim of the current research has been to prepare and characterize the co-crystals of quercetin.The present study provides useful information for the potential application of co-crystal technology for water-insoluble drugs, especially flavonoid compounds like quercetin.