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Transdermal Drug Delivery System (TDDS) is the most important part of Pharmaceutical dosage form. Transdermal Drug Delivery System (TDDS) established itself as an integral part of Novel Drug Delivery Systems On the delivery of the drug across dermis gives the systemic effect. In this study Transdermal patches were prepared by Mercury Substrate Method using ethyl cellulose polymer and Poly Vinyl Pyrrolidone (PVP) was used as a plasticizer. The prepared patches was evaluated for Thickness, Folding endurance, Drug contain uniformity, Drug content, Percent Moisture Absorption and Percent Moisture loss.

Average thickness was found to be 191, Tensile strength (2.398kg/mm2) and Drug content uniformity was found to be 9.47. In vitro permeation study was performed by using Franz diffusion cell.


TDDS Transdermal film Paracetamol Ethyl cellulose Drug polymer

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