Main Article Content
Abstract
Niosomes are nanometric in size use for drug targeting at a rate directed by the needs of body during tratment. Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic non ionic surfactant wth or without incorporation of cholestrol or either lipids and can be used as carrier of amphiphilic and lipophilic.
Niosomes (non-ionic surfactant vesicles ) were biodegradable, biocompatible, and non- immunogenic in nature and having flexibility in structure & storage. These are chemicaly stable, ecently many researchers works on niosomes by oral drug delivery to provide better bioavailability to drug. Niosomes provides better encapsulation in biological membrain and maintain stability.
Drug entraped vallues were measured by using flurosant markers like 5-6-Carboxyfluroscein and drug release rate is evaluated in biolgical media that is (serum & plasma) as a function of surfectant composition and in the presence or absence of cholesterol. Surfactant charge measurment is done by zeta potential as a function of pH , gel electrophoresis and immunoblotting were used to know the compatability study between biological fluid componant and prepared vesicles. It was found that all the vesicle carries negative charge & rapidly bound to the plasma protein which incluid albumin & imunoglobulin-G that affects the latency of entraped marker.
Uptake & degradation of niosomes in a living unicellular, eukaryotic micro-oraganism was also investigated. In this work the well chrecterise liposomes were compared with niosoms.