Main Article Content
Abstract
The aim of the present work was to develop a pulsatile drug release system of Nebivololhydrochlorideby using ethyl cellulose, xanthan gum, Hydroxy propyl methyl cellulose K15 M for the effective treatment of hypertension. This system is designed to mimic the circadian rhythm of the disease by releasing the drug after a predetermined lag time of 6 hrs. This Time controlled delivery system is capable of delivering drug when and where it is required most. All the formulations were prepared by direct compression method each consisting of a core and a coat (‘core in cup’ method). The core tablet containing the active ingredient was then coated with polymers such as Xanthan gum, Hydroxy propyl methyl cellulose K15 M and Ethyl cellulose in different proportions. These pulsatile tablets were subjected to various evaluation studies for the drug content, thickness and in-vitro release profile. The in vitro dissolution study of the prepared tablets was conducted initially for 2 hrs in simulated gastric fluid and after that medium was changed to intestinal fluid pH 7.4 for remaining 10 hrs. Among all the formulations F10 formulation showed maximum of 99% drug release, at the end of 12 hrs. It followed zero order and peppas release kinetics and thus matches with chrono-biological requirement of the disease.