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Abstract

Aim


The aim of the studyis to develop and evaluategastroretentive float tablets of metaprolol succinate and hydrochlorothiazide by using ethyl cellulose, carbopol971p, Hydroxy propyl methyl cellulose K15 M.


Materials andMethods


The bilayer tablets of metaprolol succinate and hydrochlorothiazide were prepared by direct compression method by using ethyl cellulose, carbopol 971P, Hydroxy propyl methyl cellulose K15 M in 10, 15, 20 % of each polymer.


Results


FTIR studies of the formulations showed no interaction of Metaprolol succinate and hydrochlorothiazide with the polymers used in formulation. Most of the tablet formulations showed values within the official limits for, pre and post-compression evaluation tests. The optimized formulation F9 with HPMC K15M and sodium bicarbonate showed best results based on required floating lag time of 102sec, floating duration release of 98.5% up to 16hrs.Formulaton F9 showed good results than rest of the 15 formulations in pre and post compression studies. IR-spectroscopic studies indicated that there were no drug-excipients interactions. The optimized formulation is F9 with 99.6 % in 12 hours. Drug release kinetics studies were done for F9 formulation; it followed zero order and Higuchi model release systems. The drug release from the formulation was sustained and followed non-fickian transport.


Conclusion


It is concluded bilayer technology has been successfully applied for sustained release of metaprolol succinate and immediate release of hydrochlorothiazide.

Keywords

Ethyl cellulose Carbopol 971P Hydroxy propyl methyl cellulose K15 M Zero order Non-fickian transport

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