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Abstract
The buccal mucoadhesive patches of catechin were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulations were Hydroxyl propyl methyl cellulose (HPMC E15), carboxy methyl cellulose (CMC), chitason and Vinga radiate extract. These formulations were characterized for physiochemical parameters, in vitro retention time, in vitro bioadhesive strength, percent hydration and drug release. The modified in vitro assembly was used to measure the bioadhesive strength of patches with fresh goat buccal mucosa as a model tissue. The best mucoadhesive performance and in vitro drug release profile were exhibited by the patches contains chitason and VR (vinga radiate extract) in the ratio of 1:1.5. This formulation was more comfortable to the user due to less erosion, faster hydration rate, and optimum pH of surrounding medium.