Synthesis, Characterization and Evaluation of N-Substituted Tetrahydrocarbazoles for anti-oxidant activity

Abstract

A New Class of N-Substituted Tetrahydrocabazolederivatives are prepared by in presence of reagents like glacial acetic acid leads the formation of Intermediate compounds substituted tetrahydrocabazole (3a, 3b), by using cyclohexanone and phenyl hydrazine’s using as starting material. The Intermediate compounds upon treating with 10% sodium hydroxide and substituted 4amino-benzoyl chlorides (4a, 4b) gives (4aminobenzoyl) 1, 2, 3, 4 tetrahydrocarbazole derivatives. (5a, 5b). The structures of new derivatives are characterized by ¹H NMR, IR, and Mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro anti-oxidant activity. Among these compounds the 5b shows good anti-oxidant activity due to the presence of the methyl functional group at 8^th position.