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Abstract
Microneedle delivery technology is an novel technique of administration of drug. Initially they have been used in Dermatological therapies such as acne and dark spots removal and now they are using in vaccination as they causes painless injection of the vaccine and also self-administrable. As it administration is painless and with high efficacy. Based on this technique scientists have developed an oral administrable pill which was more preferable by patients as they are easy way for administration. Microneedle pill was helpful for the patients to come from the disadvantages of injectables. The main advantage of the microneedle pill is painless and direct administration directly in to blood stream with high efficacy and high bioavailability. Microneedle pill administers directly into the blood stream at two different sites of the gastrointestinal tract that is in stomach walls and intestinal walls.