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The Floating Sustained released tablets using effervescent agent containing Lafutidine SR tablets were successfully prepared by wet granulation method. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index. The prepared granules were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 3.11±0.02, average hardness of 7.94±0.05, average weight of 300±0.05, friability of 0.45. The optimized formulation F7 which releases the Lafutidine in sustained manner in 1st hour it releases 9.3% but the remaining drug release was sustained up to 12 hours.


Lafutidine angle of repose compressibility index

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