Formulation characterization and invitro evaluation of double walled microspheres loaded with metoproplol succinate

Abstract

      In the present work, double walled microspheres of Metaprolol succinate using Sodium alginate along with Carbopol 934 and HPMC K100,Guar gum as copolymers were formulated to deliver Metaprolol succinate via oral route^1,2. The results of this investigation indicate that Solvent Evaporation method can be successfully employed to fabricate Metaprolol succinate microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. The  invitro drug release decreased with increase in the polymer and copolymer concentration. Among all formulations F7 shows Maximum drug release in 12hrs when compared with other formulations.  Analysis of drug release mechanism showed that the drug release from the formulations followed the Non fickian diffusion mechanism and follows zero order kinectics. Based on the results of evaluation tests formulation coded F7 was concluded as best formulation.