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In present work an attempt has been made to prepare Deferasirox dispersible tablets with increased rate of dissolution may leads to increase bioavailability. In present work Deferasirox dispersible tablets prepared by using different superdisintegrants8 by direct compression method. The tablets were evaluated for various parameters like weight variation, hardness, friability, in vitro disigration time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR studies and short term stability studies. drug content uniformity was in between 98.1 to 101.0%, FTIR study showed that there was no drug interaction with formulation additives of the tablet, short term stability studies of the formulations indicated that there are no significant change in hardness, friability, drug content and in vitro drug release. Best formulation was compared with that of the innovator F8 and F9 were found complying with the innovator but due to lower SLS concentration in F9 formulation it is the best formulation.


Deferasirox Dispersible Tablets and Superdisintegrants

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