https://pharmacreations.com/index.php/jpc en-US [email protected] (Dr.N.Sriram) [email protected] (Dr.N.Sriram) Mon, 05 Oct 2026 07:00:10 +0000 OJS 3.2.1.4 http://blogs.law.harvard.edu/tech/rss 60 https://pharmacreations.com/index.php/jpc/article/view/402 <p>In the present research work pulsatile drug delivery system of Bisoprolol fumarate tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopeia limits. In vitro release of Bisoprolol fumarate of core tablet formulations F1-F3, F1 showed faster drug release after 20 mins. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric coated formulations C1, C2, and C3 showed maximum drug release after 3 hours. C5 and C9 showed maximum drug release after 8^thhr. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C5 and C9 with 98.37% and 99.9%.</p> Addagaala Bhavani Durga, L. Mohan Krishna, Mandapati Bhavani, Prathipati Teja Copyright (c) 2026 Futuristic Publications https://creativecommons.org/licenses/by-nc/4.0/ https://pharmacreations.com/index.php/jpc/article/view/402 Sat, 03 Oct 2026 00:00:00 +0000 https://pharmacreations.com/index.php/jpc/article/view/423 <p><em>Acalypha Indica</em> can serve as a treatment for a number of illnesses and conditions that affect people. This herb offers nutritional qualities and a variety of medicinal uses. The plant is frequently used to cure a variety of illnesses, including those with acaricidal, antibacterial, and antifungal properties. Leaves used for the treatment of rheumatic and gouty Joints, skin diseases, also used for the treatment of Tuberculosis, nausea and nervous disorders. Chewable tablets are the tablets that are intended to disintegrate smoothly in the mouth at the modern rate either with or without actual chewing. The purpose of the tablet is to provide unit dosage form of medication that can be easily administered to infants and elderly who may have difficulty in swallowing. To prepare the chewable tablet of ethanolic extract of <em>Acalypha Indica</em> Leaves using different excipients and to evaluate that disintegrates in mouth and provide an effective treatment for constipation. To improve the oral bioavailability and onset of action is prepared in the form of mouth dissolving tablets by direct compression method. The content of the chewable tablets was found in the range between 98.00 -102.00%. Disintegration time of Acalypha indica L extract chewable tablets were found between2.00 to 3.00 minutes. Stability results revealed that there were no significant changes found in physical appearance, weight, thickness, hardness, friability, disintegration time, drug content a during the period of 3 months even after stored at 25±2°C/60%±5%RH and 40±2°C/75%±5%RH.</p> R. Gopinathan, C. Saranya, M. Radhakrishnan Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0/ https://pharmacreations.com/index.php/jpc/article/view/423 Tue, 10 Nov 2026 00:00:00 +0000