Formulation And Evaluation of Tablet Containing Leaves Extract of Aca-lypha Indica (Indian Nettle) In Masticable Form (Chewable Form)

Abstract

Acalypha Indica can serve as a treatment for a number of illnesses and conditions that affect people. This herb offers nutritional qualities and a variety of medicinal uses. The plant is frequently used to cure a variety of illnesses, including those with acaricidal, antibacterial, and antifungal properties. Leaves used for the treatment of rheumatic and gouty Joints, skin diseases, also used for the treatment of Tuberculosis, nausea and nervous disorders. Chewable tablets are the tablets that are intended to disintegrate smoothly in the mouth at the modern rate either with or without actual chewing. The purpose of the tablet is to provide unit dosage form of medication that can be easily administered to infants and elderly who may have difficulty in swallowing. To prepare the chewable tablet of ethanolic extract of Acalypha Indica Leaves using different excipients and to evaluate that disintegrates in mouth and provide an effective treatment for constipation. To improve the oral bioavailability and onset of action is prepared in the form of mouth dissolving tablets by direct compression method. The content of the chewable tablets was found in the range between 98.00 -102.00%. Disintegration time of Acalypha indica L extract chewable tablets were found between2.00 to 3.00 minutes. Stability results revealed that there were no significant changes found in physical appearance, weight, thickness, hardness, friability, disintegration time, drug content a during the period of 3 months even after stored at 25±2°C/60%±5%RH and 40±2°C/75%±5%RH.