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Abstract
In the present research work pulsatile drug delivery system of Bisoprolol fumarate tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopeia limits. In vitro release of Bisoprolol fumarate of core tablet formulations F1-F3, F1 showed faster drug release after 20 mins. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric coated formulations C1, C2, and C3 showed maximum drug release after 3 hours. C5 and C9 showed maximum drug release after 8thhr. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C5 and C9 with 98.37% and 99.9%.